A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Examining the healthy human microbiome concept
Tekijät: Joos, Raphaela; Boucher, Katy; Lavelle, Aonghus; Arumugam, Manimozhiyan; Blaser, Martin J.; Claesson, Marcus J.; Clarke, Gerard; Cotter, Paul D.; De Sordi, Luisa; Dominguez-Bello, Maria G.; Dutilh, Bas E.; Ehrlich, Stanislav D.; Ghosh, Tarini Shankar; Hill, Colin; Junot, Christophe; Lahti, Leo; Lawley, Trevor D.; Licht, Tine R.; Maguin, Emmanuelle; Makhalanyane, Thulani P.; Marchesi, Julian R.; Matthijnssens, Jelle; Raes, Jeroen; Ravel, Jacques; Salonen, Anne; Scanlan, Pauline D.; Shkoporov, Andrey; Stanton, Catherine; Thiele, Ines; Tolstoy, Igor; Walter, Jens; Yang, Bo; Yutin, Natalia; Zhernakova, Alexandra; Zwart, Hub; Doré, Joël D.; Ross, R. Paul; Human Microbiome Action Consortium
Kustantaja: NATURE PORTFOLIO
Kustannuspaikka: BERLIN
Julkaisuvuosi: 2024
Journal: Nature Reviews Microbiology
Tietokannassa oleva lehden nimi: NATURE REVIEWS MICROBIOLOGY
Lehden akronyymi: NAT REV MICROBIOL
Sivujen määrä: 14
ISSN: 1740-1526
eISSN: 1740-1534
DOI: https://doi.org/10.1038/s41579-024-01107-0
Verkko-osoite: https://doi.org/10.1038/s41579-024-01107-0
Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a 'healthy' human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome-health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.In this Perspective, Joos, Ross and colleagues reflect on current approaches and the challenges of defining a 'healthy' microbiome, and propose an updated framework for interpreting these dynamic ecosystems by incorporating concepts from epidemiology into microbiome study design.
