B2 Vertaisarvioimaton kirjan tai muun kokoomateoksen osa
Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance
Tekijät: Crisóstomo, Luís; Parena, Ae; Hyseni, Besmir; Bergman, Hans; Mildner, Alexander
Toimittaja: Malgorzata Kloc, Jacek Z. Kubiak, Marta Halasa
Kustantaja: Springer Nature Switzerland
Julkaisuvuosi: 2024
Kokoomateoksen nimi: Monocytes and Macrophages in Development, Regeneration, and Disease
Tietokannassa oleva lehden nimi: Results and problems in cell differentiation
Lehden akronyymi: Results Probl Cell Differ
Sarjan nimi: Results and Problems in Cell Differentiation
Numero sarjassa: 74
Vuosikerta: 74
Aloitussivu: 3
Lopetussivu: 54
ISBN: 978-3-031-65943-0
eISBN: 978-3-031-65944-7
ISSN: 0080-1844
eISSN: 1861-0412
DOI: https://doi.org/10.1007/978-3-031-65944-7_1
Verkko-osoite: https://doi.org/10.1007/978-3-031-65944-7_1
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/459082354
Tissue-resident macrophages are best known for their indispensable role in immunological reactions, where they contribute to immune defense and resolution of inflammation. However, recent studies have also uncovered that they provide crucial tissue-specific functions that support organ homeostasis and maintenance. Accordingly, defects in macrophage function or development can disrupt the delicate balance of organ homeostasis, leading to pathological conditions. Therefore, understanding the functions and development of macrophages within a tissue is critical for comprehending the interplay between immune and stromal cells, which together maintain organ physiology. This knowledge has clinical implications, such as in organ transplantation or irradiation, where monocyte-derived cells with different functions may replace the original macrophage population. In this chapter, we aim to provide an overview of the tissue-specific homeostatic functions of various macrophage populations, emphasizing that macrophages are essential components of each organ and play a vital role in ensuring the organism's survival, beyond their role in immunity.
Julkaisussa olevat rahoitustiedot:
We are grateful for the support from the Research Council of Finland’s Flagship InFLAMES (337530 and 357910), the Jane and Aatos Erkko Foundation, the Sigrid Juselius Foundation, the German Research Foundation (SPP2395; MI1328), and the Research Council of Finland (355727).
