A2 Refereed review article in a scientific journal
Monkeypox: A Comprehensive Review of Virology, Epidemiology, Transmission, Diagnosis, Prevention, Treatment, and Artificial Intelligence Applications
Authors: Rahmani, Erfan; Bayat, Ziba; Farrokhi, Mehrdad; Karimian, Shiva; Zahedpasha, Reza; Sabzehie, Hamed; Poor, Sepehr Ramezani; Khouzani, Parisa Jafari; Aminpour, Solmaz; Karami, Mohammad; Afsharjahanshah, Omid; Sharifi, Maryam; Dalvandi, Behnaz; Dalvandi, Reza; Esfahani, Amirhossein; Alaei, Maryam; Mirbolouk, Mahtab; Moradi, Fateme; Nozari, Amitis; Mirabedini, Seyed Mohammad Shahab; Janmohamadi, Mahrokh; Moghimi, Sara; Nikfarjam, Farzaneh; Sarnaghy, Faezeh Jalayer; Mirbolook, Amirhossein; Pirouzan, Mohammad; Virsoudi, Mozhdeh Mohammadi; Fard, Atousa Moghadam; Nikandishnoba, Mehdi; Hezarani, Hossein Boustani; Fadavighafari, Mohammadreza; Farrokhi, Masoud
Publisher: SHAHID BEHESHTI UNIV MEDICAL SCIENCES
Publishing place: TEHRAN
Publication year: 2024
Journal: Archives of Academic Emergency Medicine
Journal name in source: ARCHIVES OF ACADEMIC EMERGENCY MEDICINE
Journal acronym: ARCH ACAD EMERG MED
Article number: e70
Volume: 12
Issue: 1
Number of pages: 9
eISSN: 2645-4904
DOI: https://doi.org/10.22037/aaem.v12i1.2491
Web address : https://doi.org/10.22037/aaem.v12i1.2491
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/458939547
Monkeypox (Mpox), an uncommon zoonotic Orthopoxvirus, is commonly manifested by blisters on the skin and has a mortality rate of approximately 0-10%. Approximately two decades after the cessation of global smallpox vaccination, the number of confirmed cases of Mpox has been growing, making it the most common Orthopoxvirus infection. Therefore, in this narrative review, we aimed to shed light on recent advancements in the pathophysiology, transmission routes, epidemiology, manifestations, diagnosis, prevention, and treatment of Mpox, as well as the application of artificial intelligence (AI) methods for predicting this disease. The clinical manifestations of Mpox, including the onset of symptoms and dermatologic characteristics, are similar to those of the infamous smallpox, but Mpox is clinically milder. Notably, a key difference between smallpox and Mpox is the high prevalence of lymphadenopathy. Human-to-human, animal-to-human, and animal-to-animal transmission are the three main pathways of Mpox spread that must be considered for effective prevention, particularly during outbreaks. PCR testing, as the preferred method for diagnosing Mpox infection, can enhance early detection of new cases and thereby improve infection control measures. JYNNEOS and ACAM2000 are among the vaccines most commonly recommended for the prevention of Mpox. Brincidofovir, Cidofovir, and Tecovirimat are the primary treatments for Mpox cases. Similar to other viral infections, the best approach to managing Mpox is prevention. This can, in part, be achieved through measures such as reducing contact with individuals displaying symptoms, maintaining personal safety, and adhering to practices commonly used to prevent sexually transmitted infections.
Downloadable publication This is an electronic reprint of the original article. |  |
