Impaired Gait, Postural Instability, and Rigidity in Relation to CB1 Receptor Availability in Parkinson's Disease
: Ajalin, Riikka; Al-Abdulrasul, Haidar; Tuisku, Jouni M.; Hirvonen, Jussi; Lahdenpohja, Salla; Rinne, Juha O.; Brück, Anna
Publisher: Wiley
: 2025
: Movement Disorders
: Movement disorders : official journal of the Movement Disorder Society
: Mov Disord
: 40
: 1
: 163
: 167
: 0885-3185
: 1531-8257
DOI: https://doi.org/10.1002/mds.30042
: https://doi.org/10.1002/mds.30042
: https://research.utu.fi/converis/portal/detail/Publication/458842670
BACKGROUND: Parkinson's disease (PD), postural instability and gait disorder (PIGD) symptoms are associated with a worse prognosis for an unknown reason.
OBJECTIVE: The objective was to explore the relationship between cannabinoid receptor type 1 (CB1R) availability and motor symptoms in PD with [18F]FMPEP-d2 positron emission tomography (PET).
METHODS: Fifteen individuals with PD underwent [18F]FMPEP-d2 PET to measure cerebral CB1R availability. The Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) was used to evaluate the motor symptoms.
RESULTS: A negative correlation was observed between [18F]FMPEP-d2 VT and PIGD score (P = 0.002) as well as rigidity subscore (P < 0.001). Both clusters covered widespread areas of both hemispheres. In contrast, tremor or bradykinesia did not correlate to [18F]FMPEP-d2 VT.
CONCLUSIONS: Gait, postural instability, and rigidity in PD are associated with decreased CB1R availability, unlike tremor or bradykinesia, suggesting that the endocannabinoid system has a role in the pathophysiology of different motor symptoms in PD. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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J.O.R. was supported by grants from the Academy of Finland research grants (no.: 310962), the Sigrid Juselius Foundation, and Finnish State Research Funding (VTR). A.B. was supported by grants from the Finnish Movement Disorders Association and Finnish State Research Funding (VTR). R.A. was supported by grants from the Finnish Movement Disorders Association, Finnish State Research Funding (VTR), and Turku University research funds. H.A. was supported by grants from the Finnish Movement Disorders Association and Helsinki University research funds. J.M.T. was supported by grant from Finnish State Research Funding (VTR). S.L. was supported by grants from the Emil Aaltonen Foundation, the Finnish Concordia Fund, and Orion Research Foundation sr. The authors declare that there are no conflicts of interest relevant to this work.
