A1 Refereed original research article in a scientific journal
Real-world results of first-line immunotherapy or targeted therapy for metastatic melanoma in Finland: a cohort study
Authors: Mattila, Kalle E; Tiainen, Leena; Vikkula, Johanna; Kreutzman, Anna; Engström-Risku, Mia; Kysenius, Kai; Hölsä, Olivia; Hernesniemi, Sari; Hemmilä, Päivikki; Pystynen, Anssi; Mäkelä, Siru
Publisher: Informa UK Limited
Publication year: 2024
Journal: Future Oncology
Journal name in source: Future Oncology
Journal acronym: Future Oncol
Volume: 20
Issue: 40
First page : 3491
Last page: 3505
ISSN: 1479-6694
eISSN: 1744-8301
DOI: https://doi.org/10.1080/14796694.2024.2403329
Web address : https://doi.org/10.1080/14796694.2024.2403329
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/458351160
Aim: First-line (1L) immunotherapy has yielded superior overall survival (OS) in metastatic melanoma (MM) but some patients are ineligible for immunotherapy or need rapid response with 1L targeted therapy (TT).
Materials & methods: Retrospective cohort study of real-world patients treated with 1L immunotherapy (144 BRAF wild type, 85 BRAF-mutated) or 1L TT (143 BRAF-mutated) for MM in Finland during 2014-2021.
Results: Baseline brain metastases, liver metastases and elevated LDH were less common, 2-year OS rates were higher (60.3-63.5% vs. 33.8%) and more patients were alive without the next-line treatment (38.0-43.8% vs. 23.3%) in patients with 1L immunotherapy.
Conclusion: Real-world patients with 1L immunotherapy for MM had favorable baseline characteristics and better treatment outcomes than observed in patients with 1L TT.
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