A1 Refereed original research article in a scientific journal

Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management




AuthorsJirlow, Unni; Hossain, Iftakher; Korhonen, Otto; Depreitere, Bart; Rostami, Elham

PublisherElsevier

Publication year2024

JournalBrain and Spine

Journal name in sourceBrain and Spine

Article number103329

Volume4

eISSN2772-5294

DOIhttps://doi.org/10.1016/j.bas.2024.103329

Web address https://doi.org/10.1016/j.bas.2024.103329

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/457805975


Abstract

Introduction
Cerebral contusions (CCs) are common traumatic brain injuries known for their propensity to progress. Understanding their mechanical pathogenesis and predictive factors for progression is crucial for optimal management.

Research question
To provide an overview of current knowledge on CCs, including pathomechanisms, predictive factors of contusion progression, and management strategies.

Material and methods
A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words “cerebral contusion” together with the words “traumatic brain injury”, “pathomechanism”, “progression of contusion”, “predictive factors” and “management” alone or in combination.

Results
The management of CCs has evolved alongside the advances in neurointensive care, yet there is no consensus. Evidence on the effectiveness of early surgery, importantly, for the group which has the potential to expand, is limited. Some predictive factors for contusion progression have been identified, including age, injury mechanism, coagulopathy and initial contusion volume which could help to guide decision-making.

Discussion and conclusion
While various theories exist on pathomechanisms and several predictive factors for progression have been proposed, consensus on optimal management remains elusive. Individualized care guided by the predictive factors is essential. Challenges posed by antithrombotic medications highlight the need for early intervention strategies.

Decompressive craniectomy could serve as a potential tool in severe traumatic brain injury management including contusions. Conducting large cohort studies to refine predictive models and harmonizing management approaches would help to improve outcomes of patients with CCs.


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Funding information in the publication
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.


Last updated on 2025-27-01 at 19:39