A1 Refereed original research article in a scientific journal
Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management
Authors: Jirlow, Unni; Hossain, Iftakher; Korhonen, Otto; Depreitere, Bart; Rostami, Elham
Publisher: Elsevier
Publication year: 2024
Journal: Brain and Spine
Journal name in source: Brain and Spine
Article number: 103329
Volume: 4
eISSN: 2772-5294
DOI: https://doi.org/10.1016/j.bas.2024.103329
Web address : https://doi.org/10.1016/j.bas.2024.103329
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/457805975
Introduction
Cerebral contusions (CCs) are common traumatic brain injuries known for their propensity to progress. Understanding their mechanical pathogenesis and predictive factors for progression is crucial for optimal management.
Research question
To provide an overview of current knowledge on CCs, including pathomechanisms, predictive factors of contusion progression, and management strategies.
Material and methods
A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words “cerebral contusion” together with the words “traumatic brain injury”, “pathomechanism”, “progression of contusion”, “predictive factors” and “management” alone or in combination.
Results
The management of CCs has evolved alongside the advances in neurointensive care, yet there is no consensus. Evidence on the effectiveness of early surgery, importantly, for the group which has the potential to expand, is limited. Some predictive factors for contusion progression have been identified, including age, injury mechanism, coagulopathy and initial contusion volume which could help to guide decision-making.
Discussion and conclusion
While various theories exist on pathomechanisms and several predictive factors for progression have been proposed, consensus on optimal management remains elusive. Individualized care guided by the predictive factors is essential. Challenges posed by antithrombotic medications highlight the need for early intervention strategies.
Decompressive craniectomy could serve as a potential tool in severe traumatic brain injury management including contusions. Conducting large cohort studies to refine predictive models and harmonizing management approaches would help to improve outcomes of patients with CCs.
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Funding information in the publication:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.