A1 Refereed original research article in a scientific journal
Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis
Authors: Geng, Xiwen; Zhang, Nan; Li, Zhanrong; Zhao, Mengyang; Zhang, Hongbo; Li, Jingguo
Publisher: John Wiley & Sons
Publishing place: HOBOKEN
Publication year: 2024
Journal: Smart medicine
Journal name in source: SMART MEDICINE
Journal acronym: SMART MED
Volume: 3
Issue: 2
Number of pages: 13
ISSN: 2751-1863
eISSN: 2751-1871
DOI: https://doi.org/10.1002/SMMD.20240004(external)
Web address : https://doi.org/10.1002/SMMD.20240004(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/457733067(external)
The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we have developed antibacterial iron-doped nanozymes (Fe3+-doped nanozymes, FNEs) with distinguished capacity to fight against bacterial infections. The iron-doped nanozymes are composed of Fe3+ doped zeolitic imidazolate framework-8 (Fe/ZIF-8) and polyethylene imide (PEI), which were functionally coated on the surface of Fe/ZIF-8 and imparted the FNEs with improved water dispersibility and biocompatibility. FNEs possess a significant spontaneous peroxidase-mimic activity without the need for external stimulation, thus elevating cellular reactive oxygen species level by catalyzing local H2O2 at the infection site and resulting in bacteria damaged to death. FNEs eliminated 100% of Staphylococcus aureus within 6 h, and significantly relieved inflammation and bacterial infection levels in mice bacterial keratitis, exhibiting higher bioavailability and a superior therapeutic effect compared to conventional antibiotic eye drops. In addition, the FNEs would not generate drug resistance, suggesting that FNEs have great potential in overcoming infectious diseases caused by antimicrobial resistant bacteria.
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Funding information in the publication:
This work was financially supported by the National Natural Science Foundation of China (52173143 and 82371108), the Natural Science Foundation of Henan Province of China (242300421018 and 232300421176), the Medical Science and Technology Project of Henan Prov- ince of China (LHGJ20230042), and the Basic Science Key Project of Henan Eye Hospital (20JCZD002, 23JCZD003 and 23JCQN003). This work is part of the activities of the Åbo Akademi University Foundation (SÅA) funded Center of Excellence in Research “Mate- rials‐driven solutions for combating antimicrobial resis- tance (MADNESS).”