A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism : PET Studies in Twins Discordant for BMI
Tekijät: Lietzén, Martin S.; Mari, Andrea; Ojala, Ronja; Hentilä, Jaakko; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Saunavaara, Virva; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.
Kustantaja: MPDI
Julkaisuvuosi: 2024
Journal: Biomolecules
Tietokannassa oleva lehden nimi: Biomolecules
Artikkelin numero: 1070
Vuosikerta: 14
Numero: 9
eISSN: 2218-273X
DOI: https://doi.org/10.3390/biom14091070
Verkko-osoite: https://www.mdpi.com/2218-273X/14/9/1070
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/457720620
Obesity and sedentarism are associated with increased liver and pancreatic fat content (LFC and PFC, respectively) as well as impaired organ metabolism. Exercise training is known to decrease organ ectopic fat but its effects on organ metabolism are unclear. Genetic background affects susceptibility to obesity and the response to training. We studied the effects of regular exercise training on LFC, PFC, and metabolism in monozygotic twin pairs discordant for BMI. We recruited 12 BMI-discordant monozygotic twin pairs (age 40.4, SD 4.5 years; BMI 32.9, SD 7.6, 8 female pairs). Ten pairs completed six months of training intervention. We measured hepatic insulin-stimulated glucose uptake using [18F]FDG-PET and fat content using magnetic resonance spectroscopy before and after the intervention. At baseline LFC, PFC, gamma-glutamyl transferase (GT), and hepatic glucose uptake were significantly higher in the heavier twins compared to the leaner co-twins (p = 0.018, p = 0.02 and p = 0.01, respectively). Response to training in liver glucose uptake and GT differed between the twins (Time*group p = 0.04 and p = 0.004, respectively). Liver glucose uptake tended to decrease, and GT decreased only in the heavier twins (p = 0.032). In BMI-discordant twins, heavier twins showed higher LFC and PFC, which may underlie the observed increase in liver glucose uptake and GT. These alterations were mitigated by exercise. The small number of participants makes the results preliminary, and future research with a larger pool of participants is warranted.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
The Academy of Finland (J.C.H. decision 317332, K.H.P. decisions 272376, 314383, 335443, 266286), the Finnish Cultural Foundation (J.C.H., M.S.L., J.H.), the Finnish Cultural Foundation Varsinais-Suomi Regional Fund (R.O., J.C.H., J.H.), Kyllikki and Uolevi Lehikoinen Foundation (J.H.), the Finnish Diabetes Research Foundation (M.S.L., R.O., J.C.H., K.H.P., J.H.), Novo Nordisk Foundation (K.H.P., NNF20OC0060547, NNF17OC0027232, NNF10OC1013354), Helsinki University Hospital (K.H.P.), Government Research Funds (K.H.P.), Finnish Medical Foundation (K.H.P.), Gyllenberg Foundation (K.H.P.), Sigrid Juselius Foundation (K.H.P.), University of Helsinki (K.H.P.), State Research Funding/Hospital District of Southwest Finland (J.C.H.), Maija and Matti Vaskio Foundation (M.S.L.). The Turku Finnish University Society (R.O.) Turku University Foundation (R.O.), and Emil Aaltonen Foundation (M.S.L.).
