A1 Refereed original research article in a scientific journal
Association of IL-17A and IL-10 Polymorphisms with Juvenile Idiopathic Arthritis in Finnish Children
Authors: Möttönen, Milja; Teräsjärvi, Johanna; Rahikkala, Heidi; Kvist, Sonja; Mertsola, Jussi; He, Qiushui
Publisher: MPDI
Publication year: 2024
Journal: International Journal of Molecular Sciences
Journal name in source: International journal of molecular sciences
Journal acronym: Int J Mol Sci
Article number: 8323
Volume: 25
Issue: 15
ISSN: 1661-6596
eISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms25158323
Web address : https://www.mdpi.com/1422-0067/25/15/8323
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/457533279
To analyze the role of interleukin IL-17A and IL-10 polymorphisms in susceptibility to juvenile idiopathic arthritis (JIA), 98 Finnish children and adolescents with JIA were studied. Data from the 1000 Genomes Project, consisting of 99 healthy Finns, served as the controls. The patients were analyzed for four IL-17A and three IL-10 gene-promoter polymorphisms, and the serum IL-17A, IL-17F, IL-10, and IL-6 levels were determined. The IL-17A rs8193036 variant genotypes (CT/CC) were more common among the patients than controls, especially in those with polyarthritis (OR 1.93, 95% CI 1.11-3.36; p = 0.020). IL-17A rs2275913 minor allele A was more common in patients (OR 1.45, 95% Cl 1.08-1.94; p = 0.014) and especially among patients with oligoarthritis and polyarthritis than the controls (OR 1.61, 95%CI 1.06-2.43; p = 0.024). Carriers of the IL-17A rs4711998 variant genotype (AG/AA) had higher serum IL-17A levels than those with genotype GG. However, carriers of the variant genotypes of IL-17A rs9395767 and rs4711998 appeared to have higher IL-17F levels than those carrying wildtype. IL-10 rs1800896 variant genotypes (TC/CC) were more abundant in patients than in the controls (OR 1.97, 95%CI 1.06-3.70; p = 0.042). Carriers of the IL-10 rs1800896 variant genotypes had lower serum levels of IL-17F than those with wildtype. These data provide preliminary evidence of the roles of IL-17 and IL-10 in the pathogenesis of JIA and its subtypes in the Finnish population. However, the results should be interpreted with caution, as the number of subjects included in this study was limited.
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Funding information in the publication:
This research was funded by The Finnish Cultural Foundation, 00210761 and 00230841; the University of Turku; the Foundation for Pediatric Research; Maire Lisko Foundation; Tampere Tuberculosis Foundation, 26006205 (Q.H.); and Sigrid Juselius Foundation 240045 (Q.H.).
