A cohort study in family triads : impact of gut microbiota composition and early life exposures on intestinal resistome during the first two years of life - UTU Research Portal

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A cohort study in family triads : impact of gut microbiota composition and early life exposures on intestinal resistome during the first two years of life

Authors: Jokela, Roosa; Pärnänen, Katariina MM; Ponsero, Alise J; Lahti, Leo; Kolho, Kaija-Leena; de Vos, Willem M; Salonen, Anne

Publisher: Taylor & Francis

Publication year: 2024

Journal: Gut Microbes

Journal name in source: Gut microbes

Journal acronym: Gut Microbes

Article number: 2383746

Volume: 16

Issue: 1

ISSN: 1949-0976

eISSN: 1949-0984

DOI: https://doi.org/10.1080/19490976.2024.2383746

Web address : https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2383746

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/457452822

Abstract

Antibiotic resistance genes (ARGs) are prevalent in the infant gut microbiota and make up the intestinal resistome, representing a community ARG reservoir. This study focuses on the dynamics and persistence of ARGs in the early gut microbiota, and the effect of early exposures therein. We leveraged 2,328 stool metagenomes from 475 children in the HELMi cohort and the available parental samples to study the diversity, dynamics, and intra-familial sharing of the resistome during the first two years of life. We found higher within-family similarity of the gut resistome composition and ARG load in infant-mother pairs, and between spouses, but not in father-infant pairs. Early gut microbiota composition and development correlated with the ARG load; Bacteroides correlated positively and Bifidobacterium negatively with the load, reflecting the typical resistance levels in these taxa. Caesarean delivered infants harbored lower ARG loads, partly reflecting the scarcity of Bacteroides compared to vaginally delivered. Exposure to intrapartum or post-natal antibiotics showed only modest associations with the ARG load and composition, mainly before 12 months. Our results indicate that the resistome is strongly driven by the normal development of the microbiota in early life, and suggest importance of longer evolution of ARGs over effects of recent antibiotic exposure.

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Funding information in the publication:
This work was supported by the Academy of Finland [grants 1325103 (AS) and 339172 (AJP)]; Tekes [329/31/2015], and with grants from Pediatric Research Foundation and the Helsinki University Hospital Grant (KLK), Mary and Georg C. Ehrnrooth Foundation (AS and RJ), and the Foundation for Nutrition Research Grant, the Finnish Concordia Fund, and the University of Helsinki Doctoral school, Helsinki, Finland (RJ). Open access funded by Helsinki University Library.