A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence
Tekijät: Healy, Darren R.; Zarei, Iman; Mikkonen, Santtu; Soininen, Sonja; Viitasalo, Anna; Haapala, Eero A.; Auriola, Seppo; Hanhineva, Kati; Kolehmainen, Marjukka; Lakka, Timo A.
Kustantaja: Springer Nature
Julkaisuvuosi: 2024
Journal: Communications Biology
Tietokannassa oleva lehden nimi: Communications biology
Lehden akronyymi: Commun Biol
Artikkelin numero: 890
Vuosikerta: 7
Numero: 1
eISSN: 2399-3642
DOI: https://doi.org/10.1038/s42003-024-06146-0
Verkko-osoite: https://www.nature.com/articles/s42003-024-06146-0
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/457303881
Environmental and lifestyle factors, including air pollution, impaired diet, and low physical activity, have been associated with cardiometabolic risk factors in childhood and adolescence. However, environmental and lifestyle exposures do not exert their physiological effects in isolation. This study investigated associations between an exposome score to measure the impact of multiple exposures, including diet, physical activity, sleep duration, air pollution, and socioeconomic status, and serum metabolites measured using LC-MS and NMR, compared to the individual components of the score. A general population of 504 children aged 6-9 years at baseline was followed up for eight years. Data were analysed with linear mixed-effects models using the R software. The exposome score was associated with 31 metabolites, of which 12 metabolites were not associated with any individual exposure category. These findings highlight the value of a composite score to predict metabolic changes associated with multiple environmental and lifestyle exposures since childhood.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
The PANIC Study has received funding from Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Academy of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Pediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. Moreover, this project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 874739.
