A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Liquid metal hybrid antibacterial hydrogel scaffolds from 3D printing for wound healing
Tekijät: Li, Jinbo; Wang, Yu; Fan, Lu; Wang, Xiaoju; Shang, Luoran; Zhang, Hongbo; Zhao, Yuanjin
Kustantaja: Elsevier B.V.
Julkaisuvuosi: 2024
Journal: Chemical Engineering Journal
Tietokannassa oleva lehden nimi: Chemical Engineering Journal
Artikkelin numero: 153805
Vuosikerta: 496
ISSN: 1385-8947
eISSN: 1873-3212
DOI: https://doi.org/10.1016/j.cej.2024.153805
Verkko-osoite: https://doi.org/10.1016/j.cej.2024.153805
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/457273091
Hydrogels patches hold significant promise for wound healing. Endeavors have been dedicated to the improvement of hydrogel patch functionalities, with the aim of achieving systematic wound management. Herein, we present liquid metal (LM) hybrid antibacterial hydrogel scaffolds for wound healing via the 3D printing strategy. Gelatin/gellan gum-based hydrogel ink is adopted for printing the scaffolds, with LM microdroplets integrated within. Due to the excellent photothermal responsiveness of LM microdroplets, the LM hybrid scaffolds can convert the received near infrared light energy into heat energy, demonstrating controllable antibacterial ability. In addition, vascular endothelial growth factor is introduced into the scaffolds, which can be sustainably released and play an angiogenesis role. In vivo animal experiments demonstrate that this hydrogel scaffolds can effectively assit wound closure by eradicating bacterial infection and promoting angiogenesis. Thus, we believe that the proposed LM hybrid hydrogel scaffolds show promising prospects in wound treatment.
Julkaisussa olevat rahoitustiedot:
This study is part of the activities of the Åbo Akademi University Foundation (SÅA) funded Center of Excellence in Research “Materials-driven solutions for combating antimicrobial resistance (MADNESS)” at ÅAU. We appreciate the financial support from National Natural Science Foundation of China ( 82372145 ); the Research Fellow (Grant No. 353146 ), Research Project ( 347897 ), Solutions for Health Profile ( 336355 ), InFLAMES Flagship ( 337531 ) grants from Academy of Finland; and the Finland China Food and Health International Pilot Project funded by the Finnish Ministry of Education and Culture.
