A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Anthocyanins as natural bioactives with anti-hypertensive and atherosclerotic potential : Health benefits and recent advances
Tekijät: Xin, Meili; Xu, Aihua; Tian, Jinlong; Wang, Liang; He, Ying; Jiang, Hongzhou; Yang, Baoru; Li, Bin; Sun, Yongxin
Kustantaja: Elsevier
Julkaisuvuosi: 2024
Journal: Phytomedicine
Tietokannassa oleva lehden nimi: Phytomedicine
Artikkelin numero: 155889
Vuosikerta: 132
ISSN: 0944-7113
eISSN: 1618-095X
DOI: https://doi.org/10.1016/j.phymed.2024.155889
Verkko-osoite: https://doi.org/10.1016/j.phymed.2024.155889
Background Hypertension is a highly prevalent chronic metabolic illness affecting individuals of all age groups. Furthermore, it is a significant risk factor for the development of atherosclerosis (AS), as a correlation between hypertension and AS has been observed. However, the effective treatments for either of these disorders appear to be uncommon. Methods A systematic search of articles published in PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar databases over the last decade was performed using the following keywords: hypertension, AS, anthocyanins, antioxidants, gut microbes, health benefits, and bioactivity. Results The available research indicates that anthocyanin consumption can achieve antioxidant effects by inducing the activation of intracellular nuclear factor erythroid 2-related factor (Nrf2) and the expression of antioxidant genes. Moreover, previous reports showed that anthocyanins can enhance the human body's ability to fight against inflammation and cancer through the inhibition of inflammatory factors and the regulation of related signaling pathways. They can also protect the blood vessels and nervous system by regulating the production and function of endothelial nitric oxide synthase (eNOS). Gut microorganisms play an important role in various chronic diseases. Our research has also investigated the role of anthocyanins in the metabolism of the gut microbiota, leading to significant breakthroughs. This study not only presents a unique strategy for reducing the risk of cardiovascular diseases (CVD) without the need for medicine but also provides insights into the development and utilization of intestinal probiotic dietary supplements. Conclusion In this review, different in vitro and in vivo studies have shown that anthocyanins slow down the onset and progression of hypertension and AS through different mechanisms. In addition, gut microbial metabolites also play a crucial role in diseases through the gut-liver axis.
Julkaisussa olevat rahoitustiedot:
This work was supported by the National Natural Science Foundation of China ( U21A20273 ), and the supported by the Leading Goose Project of Zhejiang Province ( 2023C02046 ), and National Natural Science Foundation of China ( 32202074 ).
