A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Adenovirus infections after allogeneic hematopoietic cell transplantation in children and adults : a study from the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Tekijät: Styczynski, Jan; Tridello, Gloria; Knelange, Nina; Wendel, Lotus; Ljungman, Per; Mikulska, Malgorzata; Gil, Lidia; Cesaro, Simone; Averbuch, Diana; von dem Borne, Peter; Xhaard, Aliénor; Mielke, Stephan; Neven, Benedicte; Snowden, John A.; Dalle, Jean-Hugues; Rubio, Marie Thérèse; Crawley, Charles; Maertens, Johan; Kuball, Jurgen; Chevallier, Patrice; Michel, Gérard; Gabriel, Melissa; Burns, David; Wynn, Robert F.; Renard, Cecile; Blijlevens, Nicole; Jubert, Charlotte; Gedde-Dahl, Tobias; Collin, Matthew; Labussiere-Wallet, Helene; Kalwak, Krzysztof; Broers, Annoek E. C.; Yakoub-Agha, Ibrahim; Itäla-Remes, Maija; de la Camara, Rafael
Kustantaja: Springer Nature
Julkaisuvuosi: 2024
Journal: Bone Marrow Transplantation
Tietokannassa oleva lehden nimi: Bone marrow transplantation
Lehden akronyymi: Bone Marrow Transplant
Vuosikerta: 59
Numero: 10
Aloitussivu: 1402
Lopetussivu: 1412
ISSN: 0268-3369
eISSN: 1476-5365
DOI: https://doi.org/10.1038/s41409-024-02361-9
Verkko-osoite: https://www.nature.com/articles/s41409-024-02361-9
The objective of the study was the analysis of clinical types, outcomes, and risk factors associated with the outcome of adenovirus (ADV) infection, in children and adults after allo-HCT. A total number of 2529 patients (43.9% children; 56.1% adults) transplanted between 2000 and 2022 reported to the EBMT database with diagnosis of ADV infection were analyzed. ADV infection manifested mainly as viremia (62.6%) or gastrointestinal infection (17.9%). The risk of 1-year mortality was higher in adults (p = 0.0001), and in patients with ADV infection developing before day +100 (p < 0.0001). The 100-day overall survival after diagnosis of ADV infections was 79.2% in children and 71.9% in adults (p < 0.0001). Factors contributing to increased risk of death by day +100 in multivariate analysis, in children: CMV seropositivity of donor and/or recipient (p = 0.02), and Lansky/Karnofsky score <90 (p < 0.0001), while in adults: type of ADV infection (viremia or pneumonia vs gastrointestinal infection) (p = 0.0004), second or higher HCT (p = 0.0003), and shorter time from allo-HCT to ADV infection (p = 0.003). In conclusion, we have shown that in patients infected with ADV, short-term survival is better in children than adults. Factors directly related to ADV infection (time, clinical type) contribute to mortality in adults, while pre-transplant factors (CMV serostatus, Lansky/Karnofsky score) contribute to mortality in children.
