A2 Refereed review article in a scientific journal
Fabricating biomimetic materials with ice-templating for biomedical applications
Authors: Lin, Xiang; Fan, Lu; Wang, Li; Filppula, Anne M.; Yu, Yunru; Zhang, Hongbo
Publisher: WILEY
Publishing place: HOBOKEN
Publication year: 2023
Journal: Smart medicine
Journal name in source: SMART MEDICINE
Journal acronym: SMART MED
Article number: e20230017
Volume: 2
Issue: 3
Number of pages: 14
ISSN: 2751-1863
eISSN: 2751-1871
DOI: https://doi.org/10.1002/SMMD.20230017
Web address : https://doi.org/10.1002/SMMD.20230017
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/457185580
The proper organization of cells and tissues is essential for their functionalization in living organisms. To create materials that mimic natural structures, researchers have developed techniques such as patterning, templating, and printing. Although these techniques own several advantages, these processes still involve complexity, are time-consuming, and have high cost. To better simulate natural materials with micro/nanostructures that have evolved for millions of years, the use of ice templates has emerged as a promising method for producing biomimetic materials more efficiently. This article explores the historical approaches taken to produce traditional biomimetic structural biomaterials and delves into the principles underlying the ice-template method and their various applications in the creation of biomimetic materials. It also discusses the most recent biomedical uses of biomimetic materials created via ice templates, including porous microcarriers, tissue engineering scaffolds, and smart materials. Finally, the challenges and potential of current ice-template technology are analyzed.Creating materials that mimic natural structures is challenging due to the complexity, time, and cost involved in techniques such as patterning, templating, and printing. The use of ice templates has emerged as a promising method for producing biomimetic materials more efficiently. This review explores the historical approaches and principles underlying the ice-template method, recent biomedical uses, and analyzes its challenges as well as future potential. image
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