Brain lesions causing parkinsonism versus seizures map to opposite brain networks
: Schaper, Frederic L W V J; Morton-Dutton, Mae; Pacheco-Barrios, Niels; Turner, Joseph I; Drew, William; Khosravani, Sanaz; Joutsa, Juho; Fox, Michael D
Publisher: Oxford University Press
: 2024
: Brain Communications
: Brain communications
: Brain Commun
: fcae196
: 6
: 3
: 2632-1297
DOI: https://doi.org/10.1093/braincomms/fcae196
: https://academic.oup.com/braincomms/article/6/3/fcae196/7688123
: https://research.utu.fi/converis/portal/detail/Publication/457022237
Recent epidemiological studies propose an association between parkinsonism and seizures, but the direction of this association is unclear. Focal brain lesions causing new-onset parkinsonism versus seizures may provide a unique perspective on the causal relationship between the two symptoms and involved brain networks. We studied lesions causing parkinsonism versus lesions causing seizures and used the human connectome to identify their connected brain networks. Brain networks for parkinsonism and seizures were compared using spatial correlations on a group and individual lesion level. Lesions not associated with either symptom were used as controls. Lesion locations from 29 patients with parkinsonism were connected to a brain network with the opposite spatial topography (spatial r = -0.85) compared to 347 patients with lesions causing seizures. A similar inverse relationship was found when comparing the connections that were most specific on a group level (spatial r = -0.51) and on an individual lesion level (average spatial r = -0.042; P < 0.001). The substantia nigra was found to be most positively correlated to the parkinsonism network but most negatively correlated to the seizure network (spatial r > 0.8). Brain lesions causing parkinsonism versus seizures map to opposite brain networks, providing neuroanatomical insight into conflicting epidemiological evidence.
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F.L.W.V.J.S. was supported by grants from the American Epilepsy Society (846534) and National Institutes of Health (R01NS127892). J.J. was supported by grants from the Finnish Medical Foundation, Finnish Foundation for Alcohol Studies, Finnish Parkinson Foundation, Sigrid Juselius Foundation and Turku University Hospital. M.D.F. was supported by grants from the Sidney R. Baer, Jr. Foundation, the National Institutes of Health (R01NS127892, R01MH113929, R21MH126271, R56AG069086 and R21NS123813), the Nancy Lurie Marks Foundation, the Kaye Family Research Fund, the Ellison-Baszucki Foundation and the Mather’s Foundation.
