A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes
Tekijät: Lena M. Thorn, Sara Shams Daniel Gordin, Ron Liebkind, Carol Forsblom, Paula Summanen, Stefanie Hägg-Holmberg, Turgut Tatlisumak, Oili Salonen, Jukka Putaala, Juha Martola, Per-Henrik Groop; on behalf of the FinnDiane Study Group
Julkaisuvuosi: 2019
Journal: Diabetes Care
Vuosikerta: 42
Numero: 2
Aloitussivu: 327
Lopetussivu: 330
Sivujen määrä: 4
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc18-1302
Verkko-osoite: 10.2337/dc18-1302
OBJECTIVE To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.
RESEARCH DESIGN AND METHODS This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0–45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD.
RESULTS Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00–1.05], P = 0.035).
CONCLUSIONS Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects
