Does the effect of adolescent health behaviours on adult cardiometabolic health differ by socioeconomic background? Protocol for a population-based cohort study
: Jackisch, Josephine; Noor, Nazihah; Raitakari, Olli T; Lehtimäki, Terho; Kähönen, Mika; Cullati, Stéphane; Delpierre, Cyrille; Kivimäki, Mika; Carmeli, Cristian
Publisher: BMJ Publishing Group
: 2024
: BMJ Open
: BMJ open
: BMJ Open
: e078428
: 14
: 5
: 2044-6055
: 2044-6055
DOI: https://doi.org/10.1136/bmjopen-2023-078428
: https://bmjopen.bmj.com/content/14/5/e078428
: https://research.utu.fi/converis/portal/detail/Publication/454736328
Introduction Adolescence is a sensitive period for cardiometabolic health. Yet, it remains unknown if adolescent health behaviours, such as alcohol use, smoking, diet and physical activity, have differential effects across socioeconomic strata. Adopting a life-course perspective and a causal inference framework, we aim to assess whether the effects of adolescent health behaviours on adult cardiometabolic health differ by levels of neighbourhood deprivation, parental education and occupational class. Gaining a better understanding of these social disparities in susceptibility to health behaviours can inform policy initiatives that aim to improve population health and reduce socioeconomic inequalities in cardiometabolic health.
Methods and analysis We will conduct a secondary analysis of the Young Finns Study, which is a longitudinal population-based cohort study. We will use measures of health behaviours—smoking, alcohol use, fruit and vegetable consumption, and physical activity—as exposure and parental education, occupational class and neighbourhood deprivation as effect modifiers during adolescence (ages 12–18 years). Eight biomarkers of cardiometabolic health (outcomes)—waist circumference, body mass index, blood pressure, low-density lipoprotein cholesterol, apolipoprotein B, plasma glucose and insulin resistance—will be measured when participants were aged 33–40. A descriptive analysis will investigate the clustering of health behaviours. Informed by this, we will conduct a causal analysis to estimate effects of single or clustered adolescent health behaviours on cardiometabolic health conditional on socioeconomic background. This analysis will be based on a causal model implemented via a directed acyclic graph and inverse probability-weighted marginal structural models to estimate effect modification.
Ethics and dissemination The Young Finns study was conducted according to the guidelines of the Declaration of Helsinki, and the protocol was approved by ethics committees of University of Helsinki, Kuopio, Oulu, Tampere and Turku. We will disseminate findings at international conferences and a manuscript in an open-access peer-reviewed journal.
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Swiss National Science Foundation (208205). The Young Finns Study supported by the Academy of Finland: 356405, 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland (N/A); Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (X51001); Juho Vainio Foundation (N/A); Paavo Nurmi Foundation (N/A); Finnish Foundation for Cardiovascular Research (N/A); Finnish Cultural Foundation (N/A); The Sigrid Juselius Foundation (N/A); Tampere Tuberculosis Foundation(N/A); Emil Aaltonen Foundation (N/A); Yrjö Jahnsson Foundation (N/A); Signe and Ane Gyllenberg Foundation (N/A); Diabetes Research Foundation of Finnish Diabetes Association (N/A); EU Horizon 2020 (755320 for TAXINOMISIS and 848146 for To Aition); European Research Council (742927 for MULTIEPIGEN project); TUNI Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundat