A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial
Tekijät: Liikonen, Vilma; Näätänen, Mari; Kårlund, Anna; Hanhineva, Kati; Karhunen, Leila; Kolehmainen, Marjukka
Kustantaja: Cambridge University Press
Julkaisuvuosi: 2024
Journal: British Journal of Nutrition
Tietokannassa oleva lehden nimi: The British journal of nutrition
Lehden akronyymi: Br J Nutr
Vuosikerta: 132
Numero: 3
Aloitussivu: 330
Lopetussivu: 340
ISSN: 0007-1145
eISSN: 1475-2662
DOI: https://doi.org/10.1017/S0007114524001077
Verkko-osoite: https://doi.org/10.1017/S0007114524001077
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/454677725
This study aimed to investigate whether psychological distress, whole grain consumption, and tryptophan metabolism are associated in participants undergoing weight management intervention. Seventy-nine women and men (mean age 49.7 ± 9.0 years; BMI 34.2 ± 2.5 kg/m2) participated in a 7-week weight-loss period (WL), and in a 24-week weight maintenance intervention period (WM). Whole grain consumption was measured using 4-day food diaries. Psychological distress was assessed with the General Health Questionnaire-12 (GHQ), and participants were divided into three GHQ groups based on the GHQ scores before WL. Tryptophan metabolites were determined from the participants' fasting plasma using liquid chromatography-mass spectrometry. GHQ scores were not associated with the whole grain consumption. A positive association was observed between the whole grain consumption and indole propionic acid (IPA) during the WM (p = 0.033). Serotonin levels were higher after the WL in the lowest GHQ tertile (p = 0.033), while the level at the end of the WM was higher compared to other timepoints in the highest GHQ tertile (p = 0.015 and p = 0.001). This difference between groups was not statistically significant. Furthermore, levels of several tryptophan metabolites changed within the groups during the study. Tryptophan metabolism changed during the study in the whole study group, independently from the level of psychological distress. The association between whole grain consumption and IPA is possibly explained by the effects of dietary fibre on gut microbiota. This broadens the understanding of the pathways behind the health benefits associated with the intake of whole grains.
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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant number 874739 (M.K.). The LC-MS facility has received support from Biocenter Finland and biocenter Kuopio. This research was supported by the Finnish Funding Agency for Technology and Innovation, and Finnish food manufacturers (Atria Plc, Fazer Group Ltd, Arla Ingman Ltd, Valio Ltd, Sinebrychof Ltd, Vaasan Ltd, Foodfles Ltd, Leiras Finland Ltd) (L.K., grant number 40100/07); the SalWe Research Program for Mind and Body (Tekes, grant number 1104/10); the Academy of Finland (L.K., grant number 286028, 325022) (K.H., grant number 321716, 334814); Olvi -foundation (M.K., grant number 201910702); Juho Vainio Foundation (M.N., grant number 202010290); Jane and Aatos Erkko Foundation (K.H.); and Lantmännen research Foundation (K.H.). Funders had no role in the design, analysis or writing of this article.
