A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Frailty and mortality: an 18-year follow-up study among Finnish community-dwelling older people




TekijätMarika Salminen, Anna Viljanen, Sini Eloranta, Paula Viikari, Maarit Wuorela, Tero Vahlberg, Raimo Isoaho, Sirkka-Liisa Kivelä, Päivi Korhonen, Kerttu Irjala, Minna Löppönen, Laura Viikari

Julkaisuvuosi2019

JournalAging Clinical and Experimental Research

Sivujen määrä7

ISSN1594-0667

eISSN1720-8319

DOIhttps://doi.org/10.1007/s40520-019-01383-4

Verkko-osoite10.1007/s40520-019-01383-4

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/44927135


Tiivistelmä
Background

There is a lack of agreement about applicable instrument to screen frailty in clinical settings.

Aims

To analyze the association between frailty and mortality in Finnish community-dwelling older people.

Methods

This was a prospective study with 10- and 18-year follow-ups. Frailty was assessed using FRAIL scale (FS) (n = 1152), Rockwood’s frailty index (FI) (n = 1126), and PRISMA-7 (n = 1124). To analyze the association between frailty and mortality, Cox regression model was used.

Results

Prevalence of frailty varied from 2 to 24% based on the index used. In unadjusted models, frailty was associated with higher mortality according to FS (hazard ratio 7.96 [95% confidence interval 5.10–12.41] in 10-year follow-up, and 6.32 [4.17–9.57] in 18-year follow-up) and FI (5.97 [4.13–8.64], and 3.95 [3.16–4.94], respectively) in both follow-ups. Also being pre-frail was associated with higher mortality according to both indexes in both follow-ups (FS 2.19 [1.78–2.69], and 1.69 [1.46–1.96]; FI 1.81[1.25–2.62], and 1.31 [1.07–1.61], respectively). Associations persisted even after adjustments. Also according to PRISMA-7, a binary index (robust or frail), frailty was associated with higher mortality in 10- (4.41 [3.55–5.34]) and 18-year follow-ups (3.78 [3.19–4.49]).

Discussion

Frailty was associated with higher mortality risk according to all three frailty screening instrument used. Simple and fast frailty indexes, FS and PRISMA-7, seemed to be comparable with a multidimensional time-consuming FI in predicting mortality among community-dwelling Finnish older people.

Conclusions

FS and PRISMA-7 are applicable frailty screening instruments in clinical setting among community-dwelling Finnish older people.


Ladattava julkaisu

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Last updated on 2024-26-11 at 11:51