A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The impact of epididymal proteins on sperm function
Tekijät: Björkgren I., Sipilä P.
Kustantaja: BIOSCIENTIFICA LTD
Julkaisuvuosi: 2019
Journal: Reproduction
Tietokannassa oleva lehden nimi: REPRODUCTION
Lehden akronyymi: REPRODUCTION
Vuosikerta: 158
Numero: 5
Aloitussivu: R155
Lopetussivu: R167
Sivujen määrä: 13
ISSN: 1470-1626
DOI: https://doi.org/10.1530/REP-18-0589
Tiivistelmä
The epididymis is necessary for post-testicular sperm maturation as it provides the milieu required for spermatozoa to gain the ability for progressive movement and fertilization. In the epididymis the sperm protein, lipid and small RNA content are heavily modified due to interaction with luminal proteins secreted by the epididymal epithelium and extracellular vesicles, epididymosomes. This review focuses on epididymal proteins demonstrated to have an effect on sperm functions, such as motility, capacitation, acrosome reaction, sperm-zona pellucida binding and sperm-egg binding, as well as on embryonic development.
The epididymis is necessary for post-testicular sperm maturation as it provides the milieu required for spermatozoa to gain the ability for progressive movement and fertilization. In the epididymis the sperm protein, lipid and small RNA content are heavily modified due to interaction with luminal proteins secreted by the epididymal epithelium and extracellular vesicles, epididymosomes. This review focuses on epididymal proteins demonstrated to have an effect on sperm functions, such as motility, capacitation, acrosome reaction, sperm-zona pellucida binding and sperm-egg binding, as well as on embryonic development.
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