A2 Refereed review article in a scientific journal
The impact of epididymal proteins on sperm function
Authors: Björkgren I., Sipilä P.
Publisher: BIOSCIENTIFICA LTD
Publication year: 2019
Journal: Reproduction
Journal name in source: REPRODUCTION
Journal acronym: REPRODUCTION
Volume: 158
Issue: 5
First page : R155
Last page: R167
Number of pages: 13
ISSN: 1470-1626
DOI: https://doi.org/10.1530/REP-18-0589
Abstract
The epididymis is necessary for post-testicular sperm maturation as it provides the milieu required for spermatozoa to gain the ability for progressive movement and fertilization. In the epididymis the sperm protein, lipid and small RNA content are heavily modified due to interaction with luminal proteins secreted by the epididymal epithelium and extracellular vesicles, epididymosomes. This review focuses on epididymal proteins demonstrated to have an effect on sperm functions, such as motility, capacitation, acrosome reaction, sperm-zona pellucida binding and sperm-egg binding, as well as on embryonic development.
The epididymis is necessary for post-testicular sperm maturation as it provides the milieu required for spermatozoa to gain the ability for progressive movement and fertilization. In the epididymis the sperm protein, lipid and small RNA content are heavily modified due to interaction with luminal proteins secreted by the epididymal epithelium and extracellular vesicles, epididymosomes. This review focuses on epididymal proteins demonstrated to have an effect on sperm functions, such as motility, capacitation, acrosome reaction, sperm-zona pellucida binding and sperm-egg binding, as well as on embryonic development.
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