A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Rhinovirus species and tonsillar immune responses
Tekijät: Emilia Mikola, Oscar Palomares, Riitta Turunen, Matti Waris, Lotta E. Ivaska, Antti Silvoniemi, Tuomo Puhakka, Beate Rückert, Tytti Vuorinen, Mübeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Kustantaja: BMC
Julkaisuvuosi: 2019
Journal: Clinical and Translational Allergy
Tietokannassa oleva lehden nimi: CLINICAL AND TRANSLATIONAL ALLERGY
Lehden akronyymi: CLIN TRANSL ALLERGY
Artikkelin numero: ARTN 63
Vuosikerta: 9
Numero: 1
Sivujen määrä: 9
eISSN: 2045-7022
DOI: https://doi.org/10.1186/s13601-019-0302-7
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/44102432
Background Rhinovirus A and C infections are important contributors to asthma induction and exacerbations. No data exist on the interaction of local immune responses in rhinovirus infection. Therefore, we aimed to determine the tonsillar immune responses according to rhinovirus A, B and C infections. Methods We collected tonsillar samples, nasopharyngeal aspirates and peripheral blood from 42 rhinovirus positive tonsillectomy patients. Fifteen respiratory viruses or their types were investigated from nasopharynx and tonsil tissue, and rhinovirus species were typed. The expression of 10 cytokines and 4 transcription factors (IFN-alpha, IFN-beta, IFN-gamma, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-beta, FOXP3, GATA3, RORC2 and Tbet) were studied from tonsil tissue by quantitative PCR. A standard questionnaire of respiratory symptoms and health was filled by the patient or his/her guardian. The patients were divided into three groups by the determination of rhinovirus species. Results Overall, 16 patients had rhinovirus A, 12 rhinovirus B and 14 rhinovirus C infection. In rhinovirus B positive group there were significantly less men (P = 0.0072), less operated in spring (P = 0.0096) and more operated in fall (P = 0.030) than in rhinovirus A or C groups. Rhinovirus A positive patients had more respiratory symptoms (P = 0.0074) and particularly rhinitis (P = 0.036) on the operation day. There were no significant differences between the groups in virus codetection. In adjusted analysis, rhinovirus C infections were associated with increased IFN-alpha (P = 0.045) and decreased RORC2 expression (P = 0.025). Conclusions Rhinovirus species associated differently with clinical characteristics and tonsillar cytokine responses.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
