A1 Journal article – refereed

Diffusion tensor imaging is associated with motor outcomes of very preterm born children at 11 years of age




List of Authors: Katri Lahti, Virva Saunavaara, Petriina Munck, Karoliina Uusitalo, Mari Koivisto, Riitta Parkkola, Leena Haataja, Annarilla Ahtola, Mikael Ekblad, Satu Ekblad, Eeva Ekholm, Leena Haataja, Mira Huhtala, Jere Jaakkola, Max Karukivi, Pentti Kero, Riikka Korja, Katri Lahti, Helena Lapinleimu, Liisa Lehtonen, Tuomo Lehtonen, Marika Leppänen, Annika Lind, Hanna Manninen, Mari Koivisto, Mira Mattson,Jonna Maunu, Petriina Munck, Laura Määttänen, Pekka Niemi, Anna Nyman, Pertti Palo, Riitta Parkkola, Liisi Ripatti, Päivi Rautava, Katriina Saarinen, Virva Saunavaara, Sirkku Setänen, Matti Sillanpää, Suvi Stolt, Päivi Tuomikoski‐Koiranen, Timo Tuovinen, Karoliina Uusitalo, Anniina Väliaho, Milla Ylijoki

Publisher: WILEY

Publication year: 2020

Journal: Acta Paediatrica

Journal name in source: ACTA PAEDIATRICA

Journal acronym: ACTA PAEDIATR

Volume number: 109

Issue number: 4

Number of pages: 8

ISSN: 0803-5253

eISSN: 1651-2227

DOI: http://dx.doi.org/10.1111/apa.15004


Abstract
Aim Very preterm children born <32 weeks of gestation are at risk for motor difficulties such as cerebral palsy and developmental coordination disorder. This study explores the association between diffusion tensor imaging metrics at term and motor outcomes at 11 years of age. Methods A cohort of 37 very preterm infants (mean gestational age 29 4/7, SD 2 0/7) born in 2004-2006 in Turku University Hospital underwent diffusion tensor imaging at term. A region of interest analysis of fractional anisotropy and mean diffusivity was performed. Motor outcomes at 11 years of age were measured with the Movement Assessment Battery for Children - Second Edition. Results The diffusion metrics of the corpus callosum (genu P = .005, splenium P = .049), the left corona radiata (P = .035) and the right optic radiation (P = .017) were related to later motor performance. Mean diffusivity decreased and fractional anisotropy increased in proportion to the improving performance. Conclusion The diffusion metrics of the genu and splenium of the corpus callosum, the left corona radiata and the right optic radiation at term were associated with motor skills at 11 years of age. Diffusion tensor imaging should be further studied as a potential tool in recognising children at risk for motor impairment.

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Last updated on 2021-24-06 at 12:10