B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä

Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis




TekijätKaasinen Valtteri, Joutsa Juho, Rissanen Eero, Airas Laura, Soilu-Hänninen Merja, Noponen Tommi

KustantajaElsevier B.V.

Julkaisuvuosi2019

JournalMultiple Sclerosis and Related Disorders

Tietokannassa oleva lehden nimiMultiple Sclerosis and Related Disorders

Artikkelin numero101385

Vuosikerta36

Sivujen määrä3

ISSN2211-0348

eISSN2211-0356

DOIhttps://doi.org/10.1016/j.msard.2019.101385

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/43713416


Tiivistelmä

Dopamine has a modulatory role in a number of autoimmune diseases, but there are no published cases of longitudinal dopaminergic imaging in multiple sclerosis (MS). Here we report a patient with primary progressive multiple sclerosis (PPMS) who was scanned twice with brain dopamine transporter single photon emission computed tomography (SPECT) with an interval of four years. The results showed a loss of tracer binding that corresponded to a 4–7 fold steeper decline than in normal ageing. The finding points to a relevant role of nigrostriatal dopaminergic degeneration in the pathological process of PPMS.


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