A2 Refereed review article in a scientific journal
Cell matrix adhesion in cell migration
Authors: Conway JRW, Jacquemet G
Publisher: Portland Press Ltd.
Publication year: 2019
Journal: Essays in Biochemistry
Journal name in source: Essays in biochemistry
Journal acronym: Essays Biochem
Volume: 63
Issue: 5
First page : 535
Last page: 551
ISSN: 0071-1365
eISSN: 1744-1358
DOI: https://doi.org/10.1042/EBC20190012
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/43671584
Abstract
The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.
The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.
Downloadable publication This is an electronic reprint of the original article. |  |
UTU Research Portal