A2 Review article in a scientific journal

Cell matrix adhesion in cell migration

List of Authors: Conway JRW, Jacquemet G

Publisher: Portland Press Ltd.

Publication year: 2019

Journal: Essays in Biochemistry

Journal name in source: Essays in biochemistry

Journal acronym: Essays Biochem

Volume number: 63

Issue number: 5

ISSN: 0071-1365

eISSN: 1744-1358

DOI: http://dx.doi.org/10.1042/EBC20190012

The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.

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Last updated on 2021-20-10 at 12:44