A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood
Tekijät: Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David P. Burgner, Anna Czajko,
Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J. Amor,
Lex W. Doyle, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain,
Robert McLachlan, Richard Saffery
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2019
Journal: Nature Communications
Tietokannassa oleva lehden nimi: NATURE COMMUNICATIONS
Lehden akronyymi: NAT COMMUN
Artikkelin numero: ARTN 3922
Vuosikerta: 10
Sivujen määrä: 12
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-019-11929-9
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/42556666
More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22-35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
