Radiosynthesis of [I-123]N-(3-iodoprop-(2E)-enyl)-2 alpha-(imino-methyl)-3 beta-(3 ',4 '-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

: Yu MX, Airaksinen AJ, Gee AD, Lotjonen S, Kuikka JT, Vepsalainen JJ, Hiltunen J, Bergstrom KA

Publisher: WILEY

: 2002

: Journal of Labelled Compounds and Radiopharmaceuticals

: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

: J LABELLED COMPD RAD

: 45

: 12

: 1011

: 1017

: 7

: 0362-4803

DOI: https://doi.org/10.1002/jlcr.619

The radiosynthesis of a novel tropane derivative [I-123]KUC-25019, [[I-123] N-(3-iodoprop-(2E)-enyl)-2alpha-(imino-methyl)-3beta-(3',4'-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the I-123-labeling synthesis. The no-carrier-added I-123-labeling has about 20% yield, the specific activity of [I-123]KUC-25019 is > 107 GBq/ mumol and the radiochemical purity of [I-123] KUC-25019 is >95%. Copyright (C) 2002 John Wiley Sons, Ltd.