A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Radiosynthesis of [I-123]N-(3-iodoprop-(2E)-enyl)-2 alpha-(imino-methyl)-3 beta-(3 ',4 '-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter
Tekijät: Yu MX, Airaksinen AJ, Gee AD, Lotjonen S, Kuikka JT, Vepsalainen JJ, Hiltunen J, Bergstrom KA
Kustantaja: WILEY
Julkaisuvuosi: 2002
Journal: Journal of Labelled Compounds and Radiopharmaceuticals
Tietokannassa oleva lehden nimi: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Lehden akronyymi: J LABELLED COMPD RAD
Vuosikerta: 45
Numero: 12
Aloitussivu: 1011
Lopetussivu: 1017
Sivujen määrä: 7
ISSN: 0362-4803
DOI: https://doi.org/10.1002/jlcr.619
Tiivistelmä
The radiosynthesis of a novel tropane derivative [I-123]KUC-25019, [[I-123] N-(3-iodoprop-(2E)-enyl)-2alpha-(imino-methyl)-3beta-(3',4'-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the I-123-labeling synthesis. The no-carrier-added I-123-labeling has about 20% yield, the specific activity of [I-123]KUC-25019 is > 107 GBq/ mumol and the radiochemical purity of [I-123] KUC-25019 is >95%. Copyright (C) 2002 John Wiley Sons, Ltd.
The radiosynthesis of a novel tropane derivative [I-123]KUC-25019, [[I-123] N-(3-iodoprop-(2E)-enyl)-2alpha-(imino-methyl)-3beta-(3',4'-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the I-123-labeling synthesis. The no-carrier-added I-123-labeling has about 20% yield, the specific activity of [I-123]KUC-25019 is > 107 GBq/ mumol and the radiochemical purity of [I-123] KUC-25019 is >95%. Copyright (C) 2002 John Wiley Sons, Ltd.
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