A1 Refereed original research article in a scientific journal
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
Authors: Russell JT, Roesch LFW, Ordberg M, Ilonen J, Atkinson MA, Schatz DA, Triplett EW, Ludvigsson J
Publisher: NATURE PUBLISHING GROUP
Publication year: 2019
Journal: Nature Communications
Journal name in source: NATURE COMMUNICATIONS
Journal acronym: NAT COMMUN
Article number: 3621
Volume: 10
Number of pages: 12
ISSN: 2041-1723
eISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-019-11460-x
Web address : https://www.nature.com/articles/s41467-019-11460-x
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/42011802
Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in the development of type 1 diabetes and celiac disease. Despite this, little is known about HLA influences on the composition of the human gut microbiome, a potential source of environmental influence on disease. Here, using a general population cohort from the All Babies in Southeast Sweden study, we report that genetic risk for developing type 1 diabetes autoimmunity is associated with distinct changes in the gut microbiome. Both the core microbiome and beta diversity differ with HLA risk group and genotype. In addition, protective HLA haplotypes are associated with bacterial genera Intestinibacter and Romboutsia. Thus, general population cohorts are valuable in identifying potential environmental triggers or protective factors for autoimmune diseases that may otherwise be masked by strong genetic control.
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