A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [I-123]FP-CIT SPECT
Tekijät: Elina Jaakkola, Juho Joutsa, Elina Mäkinen, Tommi Noponen, Miia Pitkonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
Kustantaja: ELSEVIER
Julkaisuvuosi: 2019
Journal: Journal of the Neurological Sciences
Tietokannassa oleva lehden nimi: JOURNAL OF THE NEUROLOGICAL SCIENCES
Lehden akronyymi: J NEUROL SCI
Vuosikerta: 404
Aloitussivu: 124
Lopetussivu: 127
Sivujen määrä: 4
ISSN: 0022-510X
eISSN: 1878-5883
DOI: https://doi.org/10.1016/j.jns.2019.07.025
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/41981420
Background: Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and thus, it is not known whether NMSs could be used to differentiate PD from parkinsonism/tremor without dopamine deficiency.Methods: We prospectively evaluated NMSs immediately before brain dopamine transporter (DAT) [I-123]FP-CIT SPECT scanning in 193 patients with unclear parkinsonism/tremor. According to the clinical follow-up and imaging results, 84 patients had PD. NMSs and their correlations with striatal DAT binding were investigated in PD patients and in parkinsonism/tremor patients with normal dopamine function.Results: Total NMS burden, anxiety or depression did not differ between PD patients and patients with normal DAT binding. DAT-normal patients reported more perception-related (p = 0.045) and attention/memory-related NMSs than PD patients (p < 0.001). Total NMS score did not correlate with striatal DAT binding in either group.Conclusions: In clinically uncertain cases, the total NMS burden cannot be used as a tool in distinguishing PD patients from patients with non-dopaminergic parkinsonism/tremor. Clinical screening of NMSs appears equally important in all patients with parkinsonism.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
