A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Parachlamydia acanthamoebae Detected during a Pneumonia Outbreak in Southeastern Finland, in 2017-2018




TekijätHokynar K, Kurkela S, Nieminen T, Saxen H, Vesterinen EJ, Mannonen L, Pietikainen R, Puolakkainen M

KustantajaMDPI

Julkaisuvuosi2019

JournalMicroorganisms

Tietokannassa oleva lehden nimiMICROORGANISMS

Lehden akronyymiMICROORGANISMS

Artikkelin numero141

Vuosikerta7

Numero5

Sivujen määrä9

ISSN2076-2607

eISSN2076-2607

DOIhttps://doi.org/10.3390/microorganisms7050141

Verkko-osoitehttps://www.mdpi.com/2076-2607/7/5/141

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/41310717


Tiivistelmä
Community-acquired pneumonia (CAP) is a common disease responsible for significant morbidity and mortality. However, the definite etiology of CAP often remains unresolved, suggesting that unknown agents of pneumonia remain to be identified. The recently discovered members of the order Chlamydiales, Chlamydia-related bacteria (CRB), are considered as possible emerging agents of CAP. Parachlamydia acanthamoebae is the most studied candidate. It survives and replicates inside free-living amoeba, which it might potentially use as a vehicle to infect animals and humans. A Mycoplasma pneumoniae outbreak was observed in Kymenlaakso region in Southeastern Finland during August 2017-January 2018. We determined the occurrence of Chlamydiales bacteria and their natural host, free-living amoeba in respiratory specimens collected during this outbreak with molecular methods. Altogether, 22/278 (7.9%) of the samples contained Chlamydiales DNA. By sequence analysis, majority of the CRBs detected were members of the Parachlamydiaceae family. Amoebal DNA was not detected within the sample material. Our study further proposes that Parachlamydiaceae could be a potential agent causing atypical CAP in children and adolescents.

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