A1 Refereed original research article in a scientific journal

Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019




AuthorsKaisu Rantakokko-Jalava, Kati Hokynar, Niina Hieta, Anniina Keskitalo, Pia Jokela, Anna Muotiala, T. Sakari Jokiranta, Rutta Kuusela, Hannu Sarkkinen, Janne Aittoniemi, Tytti Vuorinen, Antti J. Hakanen, Mirja Puolakkainen

PublisherEUR CENTRE DIS PREVENTION & CONTROL

Publication year2019

JournalEurosurveillance

Journal name in sourceEUROSURVEILLANCE

Journal acronymEUROSURVEILLANCE

Article numberARTN 1900298

Volume24

Issue22

First page 2

Last page5

Number of pages5

ISSN1560-7917

DOIhttps://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/41233824


Abstract
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.

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Last updated on 2024-26-11 at 16:45