A1 Refereed original research article in a scientific journal
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
Authors: Kaisu Rantakokko-Jalava, Kati Hokynar, Niina Hieta, Anniina Keskitalo, Pia Jokela, Anna Muotiala, T. Sakari Jokiranta, Rutta Kuusela, Hannu Sarkkinen, Janne Aittoniemi, Tytti Vuorinen, Antti J. Hakanen, Mirja Puolakkainen
Publisher: EUR CENTRE DIS PREVENTION & CONTROL
Publication year: 2019
Journal: Eurosurveillance
Journal name in source: EUROSURVEILLANCE
Journal acronym: EUROSURVEILLANCE
Article number: ARTN 1900298
Volume: 24
Issue: 22
First page : 2
Last page: 5
Number of pages: 5
ISSN: 1560-7917
DOI: https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/41233824
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.
Downloadable publication This is an electronic reprint of the original article. |