A1 Refereed original research article in a scientific journal

Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019



Authors: Kaisu Rantakokko-Jalava, Kati Hokynar, Niina Hieta, Anniina Keskitalo, Pia Jokela, Anna Muotiala, T. Sakari Jokiranta, Rutta Kuusela, Hannu Sarkkinen, Janne Aittoniemi, Tytti Vuorinen, Antti J. Hakanen, Mirja Puolakkainen

Publisher: EUR CENTRE DIS PREVENTION & CONTROL

Publication year: 2019

Journal: Eurosurveillance

Journal name in source: EUROSURVEILLANCE

Journal acronym: EUROSURVEILLANCE

Article number: ARTN 1900298

Volume: 24

Issue: 22

First page : 2

Last page: 5

Number of pages: 5

ISSN: 1560-7917

DOI: https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298(external)

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/41233824(external)


Abstract
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.

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Last updated on 2024-26-11 at 16:45