A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood: The International Childhood Cardiovascular Cohort Consortium
Tekijät: Urbina EM, Khoury PR, Bazzano L, Burns TL, Daniels S, Dwyer T, Hu T, Jacobs DR, Juonala M, Prineas R, Raitakari O, Steinberger J, Venn A, Woo JG, Sinaiko A
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2019
Journal: Hypertension
Tietokannassa oleva lehden nimi: HYPERTENSION
Lehden akronyymi: HYPERTENSION
Vuosikerta: 73
Numero: 6
Aloitussivu: 1224
Lopetussivu: 1230
Sivujen määrä: 7
ISSN: 0194-911X
eISSN: Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.118.12334
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/41088230
Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7% black, 27.6% white, 20.9% other; P<0.0001) and female (26.4% females, 32.9% male, P<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X-2<0.0001) from 19% in children with a systolic BP% persistently below the median to 80% for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
