The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes



: Jaakkola U, Kakko T, Seppala H, Vainio-Jylha E, Vahlberg T, Raitakari OT, Kallio J

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

: 2010

: Microvascular Research

: MICROVASCULAR RESEARCH

: MICROVASC RES

: 3

: 80

: 3

: 433

: 439

: 7

: 0026-2862

DOI: https://doi.org/10.1016/j.mvr.2010.07.010


Conclusions/interpretations: Diabetes patients with the Pro7 allele display increased levels of inflammatory molecules and NPY in blood, preceding vascular wall thickening and impaired endothelial dilatation, especially in male patients. (C) 2010 Elsevier Inc. All rights reserved.




Last updated on 2024-26-11 at 20:20