The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes - UTU Research Portal

A1 Refereed original research article in a scientific journal

The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes

Authors: Jaakkola U, Kakko T, Seppala H, Vainio-Jylha E, Vahlberg T, Raitakari OT, Kallio J

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

Publication year: 2010

Journal: Microvascular Research

Journal name in source: MICROVASCULAR RESEARCH

Journal acronym: MICROVASC RES

Number in series: 3

Volume: 80

Issue: 3

First page : 433

Last page: 439

Number of pages: 7

ISSN: 0026-2862

DOI: https://doi.org/10.1016/j.mvr.2010.07.010

Abstract

Conclusions/interpretations: Diabetes patients with the Pro7 allele display increased levels of inflammatory molecules and NPY in blood, preceding vascular wall thickening and impaired endothelial dilatation, especially in male patients. (C) 2010 Elsevier Inc. All rights reserved.