A1 Refereed original research article in a scientific journal

Non-curative treatment of patients with oral tongue squamous-cell carcinoma




AuthorsMroueh R, Haapaniemi A, Saarto T, Grönholm L, Grénman R, Salo T, Mäkitie AA

Publication year2019

JournalHead and Neck

Volume276

Issue2

First page 2039

Last page2045

Number of pages7

ISSN0937-4477

DOIhttps://doi.org/10.1007/s00405-019-05456-y

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/40419116


Abstract
Purpose

Late-stage OTSCC is associated with poor overall survival (OS). Non-curative treatment approach aims to improve quality of life and prolong survival of patients deemed incurable. The purpose of this study was to investigate the used non-curative treatment modalities for OTSSC and patient survival.

Methods

All patients diagnosed with OTSCC and treated with non-curative intent at the HUS Helsinki University Hospital (Helsinki, Finland) during the 12-year period of 2005–2016 were included. Survival analysis after the non-curative treatment decision was conducted using the Kaplan–Meier method in this population-based study.

Results

Eighty-two patients were identified. A non-curative treatment decision was made at presentation without any previous treatment in 26 patients (7% of all patients diagnosed with OTSCC during the study period). Palliative radiotherapy was administered to 24% of all patients. The average survival time after the non-curative treatment decision was 3.7 months (median 2 and range 0–26).

Conclusions

Due to the short mean survival time after decision for treatment with non-curative intent, and the notable symptom burden in this patient population, a prompt initiation of all non-curative measures is warranted.


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Last updated on 2024-26-11 at 23:12