A1 Refereed original research article in a scientific journal
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits
Authors: Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FAJL, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perala MM, Jonsson A, Muka T, Kalafati IP, Mikkila V, Ordovas JM; for the CHARGE Nutrition Study Group
Publisher: AMER DIABETES ASSOC
Publication year: 2015
Journal: Diabetes Care
Journal name in source: DIABETES CARE
Journal acronym: DIABETES CARE
Volume: 38
Issue: 8
First page : 1456
Last page: 1466
Number of pages: 11
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc14-2709
Our results suggest that lower carbohydrate intake and normal sleep duration may ameliorate cardiometabolic abnormalities conferred by common circadian-related genetic variants. Until further mechanistic examination of the nominally significant interactions is conducted, recommendations applicable to the general population regarding diet-specifically higher carbohydrate and lower fat composition-and normal sleep duration should continue to be emphasized among individuals with the investigated circadian-related gene variants.
