A1 Refereed original research article in a scientific journal
Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study
Authors: Menditto E, Costa E, Midao L, Bosnic-Anticevich S, Novellino E, Bialek S, Briedis V, Mair A, Rajabian-Soderlund R, Arnavielhe S, Bedbrook A, Czarlewski W, Annesi-Maesano I, Anto JM, Devillier P, De Vries G, Keil T, Sheikh A, Orlando V, Larenas-Linnemann D, Cecchi L, De Feo G, Illario M, Stellato C, Fonseca J, Malva J, Morais-Almeida M, Pereira AM, Todo-Bom AM, Kvedariene V, Valiulis A, Bergmann KC, Klimek L, Mosges R, Pfaar O, Zuberbier T, Cardona V, Mullol J, Papadopoulos NG, Prokopakis EP, Bewick M, Ryan D, Roller-Wirnsberger RE, Tomazic PV, Cruz AA, Kuna P, Samolinski B, Fokkens WJ, Reitsma S, Bosse I, Fontaine JF, Laune D, Haahtela T, Toppila-Salmi S, Bachert C, Hellings PW, Melen E, Wickman M, Bindslev-Jensen C, Eller E, O'Hehir RE, Cingi C, Gemicioglu B, Kalayci O, Ivancevich JC, Bousquet J, Bousquet J, Hellings PW, Aberer W, Agache I, Akdis CA, Akdis M, Aliberti MR, Almeida R, Amat F, Angles R, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielle S, Asayag E, Asarnoj A, Arshad H, Avolio F, Bacci E, Bachert C, Baiar-Dini I, Barbara C, Barbagallo M, Baroni I, Barreto BA, Basagana X, Bateman ED, Bedolla-Barajas M, Bedbrook A, Bewick M, Beghe B, Bel EH, Bergmann KC, Bennoor KS, Benson M, Bertorello L, Bialoszewski AZ, Bieber T, Bialek S, Bindslev-Jensen C, Bjermer L, Blain H, Blasi F, Blua A, Marciniak MB, Bogus-Buczynska I, Boner AL, Bonini M, Bonini S, Bosnic-Anticevich CS, Bosse I, Bouchard J, Boulet LP, Bourret R, Bousquet P, Braido F, Briedis V, Brightling CE, Brozek J, Bucca C, Buhl R, Buonaiuto R, Panaitescu C, Cabanas MTB, Burte E, Bush A, Caballero-Fonseca F, Caillaud D, Caimmi D, Calderon MA, Camargos PAM, Camuzat T, Canfora G, Canonica GW, Cardona V, Carlsen KH, Carreiro-Martins P, Carriazo AM, Carr W, Cartier C, Casale T, Castellano G, Cecchi L, Cepeda AM, Chavannes NH, Chen Y, Chiron R, Chivato T, Chkhartishvili E, Chuchalin AG, Chung KF, Ciaravolo MM, Ciceran A, Cingi C, Ciprandi G, Coehlo ACC, Colas L, Colgan E, Coll J, Conforti D, De Sousa JC, Cortes-Grimaldo RM, Corti F, Costa E, Mc Costa-Dominguez, Al Courbis, Cox L, Crescenzo M, Cruz AA, Custovic A, Czarlewski W, Dahlen SE, D'Amato, Dario C, da Silva J, Dauvilliers Y, Darsow U, De Blay F, De Carlo G, Dedeu T, Emerson MDF, De Feo G, De Vries G, De Martino B, Rubina NPM, Deleanu D, Demoly P, Denburg J, Devillier P, Ercolano SDC, Di Carluccio N, Didier A, Dokic D, Dominguez-Silva MG, Douagui H, Dray G, Dubakiene R, Durham SR, Du Toit G, Dykewicz MS, El-Gamal Y, Eklund P, Eller E, Emuzyte R, Farrell J, Farsi A, De Mello JF, Ferrero J, Fink-Wagner A, Fiocchi A, Fok-Kens WJ, Fonseca J, Fontaine JF, Forti S, Fuentes-Perez JM, Galvez-Romero JL, Gamkrelidze A, Garcia-Aymerich J, Garcia-Cobas CY, Garcia-Cruz MH, Gemicioglu B, Genova S, Christoff G, Gereda JE, Van Wijk RG, Gomez RM, Gomez-Vera J, Diaz SG, Gotua M, Grisle I, Guidacci M, Guldemond N, Gutter Z, Guzman M, Haahtela T, Hajjam J, Hernandez L, Houri-Hane J, Huerta-Villalobos YR, Humbert M, Iaccarino G, Illario M, Ispayeva Z, Ivancevich JC, Jares E, Jassem E, Johnston SL, Joos G, Jung KS, Just J, Jutel M, Kaidashev I, Kalayci O, Kalyoncu AF, Karjalainen J, Kardas P, Keil T, Keith PK, Khaitov M, Khaltaev N, Kleine-Tebbe J, Klimek L, Kowalski ML, Kuitunen M, Kull I, Kuna P, Kupczyk M, Kvedariene V, Krzych-Falta E, Lacwik P, Larenas-Linnemann D, Laune D, Lauri D, Lavrut J, L TT, Lessa M, Levato G, Li J, Lieberman P, Liplec A, Lipworth B, Carlsen KCL, Louis R, Lourenco O, Luna-Pech JA, Magnan A, Mahboub B, Maier D, Mair A, Majer I, Malva J, Mandajieva E, Manning P, Keenoy EDM, Marshall GD, Masjedi MR, Maspero JF, Mathieu-Dupas E, Campos JJM, Al Matos, Maurer M, Mavale-Manuel S, Mayora O, Medina-Avalos MA, Melen E, Melo-Gomes E, Meltzer E, Menditto E, Mercier J, Miculinic N, Mihaltan F, Milenkovic B, Moda G, Mogica-Martinez MD, Mohammad Y, Momas I, Monte-Fort S, Monti R, Bogado DM, Morais-Almeida M, Morato-Castro, Mosges R, Mota-Pinto A, Santo PM, Mullol J, Munter L, Muraro A, Murray R, Naclerio R, Nadif R, Nalin M, Napoli L, Namazova-Baranova L, Neffen H, Niedeberger V, Nekam K, Neou A, Nieto A, Nogueira-Silva L, Nogues M, Novellino E, Nyembue T, O'Hehir R, Odzhakova C, Ohta K, Okamoto Y, Okubo K, Onorato GL, Cisneros MO, Ouedraogo S, Pali-Scholl I, Palkonen S, Panzner P, Papadopoulos NG, Park HS, Papi A, Passalacqua G, Paulino E, Pawankar R, Pedersen S, Pepin JL, Pereira AM, Persico M, Pfaar O, Phillips J, Picard R, Pigearias B, Pin I, Pitsios C, Plavec D, Pohl W, Popov TA, Portejoie F, Potter P, Pozzi AC, Price D, Prokopakis EP, Puy R, Pugin B, Ross REP, Przemecka M, Rabe KF, Raciborski F, Raja-Bian-Soderlund R, Reitsma S, Ribeirinho I, Rimmer J, Riv-Ero-Yeverino D, Rizzo JA, Rizzo MC, Robalo-Cordeiro C, Rodenas F, Rodo X, Gonzalez MR, Rodriguez-Manas L, Rolland C, Valle SR, Rodriguez MR, Romano A, Rodriguez-Zagal E, Rolla G, Roller-Wirnsberger RE, Romano M, Rosado-Pinto J, Rosario N, Rottem M, Ryan D, Sagara H, Salimaki J, Samolinski B, Sanchez-Borges M, Sastre-Dominguez J, Scadding GK, Schunemann HJ, Scichilone N, Schmid-Grendelmeier P, Serpa FS, Shamai S, Sheikh A, Sierra M, Simons FER, Sir-Oux V, Sisul JC, Skrindo I, Sole D, Somekh D, Sonder-Mann M, Sooronbaev T, Sova M, Sorensen M, Sorlini M, Spranger O, Stellato C, Stelmach R, Stukas R, Sunyer J, Strozek J, Szylling A, Tebyrica J, Thibaudon M, To T, Todo-Bom A, Tomazic PV, Toppila-Salmi S, Trama U, Triggiani M, Ulrik CS, Urrutia-Pereira M, Valenta R, Valero A, Valiulis A, Valovirta E, Van Eerd M, Van Ganse E, Van Hague M, Vandenplas O, Ventura MT, Vezzani G, Vasankari T, Vatrella A, Verissimo MT, Viart F, Viegi G, Vicheva D, Vontetsianos T, Wagenmann M, Walker S, Wallace D, Wang DY, Waserman S, Werfel T, Westman M, Wickman M, Williams DM, Williams S, Wilson N, Wright J, Wroczynski P, Yakovliev P, Yawn BP, Yiallouros PK, Yorgancioglu A, Yusuf OM, Zar HJ, Zhang L, Zhong N, Zernotti ME, Zhanat I, Zidarn M, Zuberbier T, Zubrinich C, Zurkuhlen A, Zuberbier T, Zubrinich C, Zurkuhlen A, Zernotti ME, Zhong N, Zidarn M, Zhanat I, Yusuf OM, Yorgancioglu A, Zhang L, Zar HJ, Yakovliev P, Wroczynski P, Yiallouros PK, Yawn BP, Wright J
Publisher: WILEY
Publication year: 2019
Journal: Clinical and Experimental Allergy
Journal name in source: CLINICAL AND EXPERIMENTAL ALLERGY
Journal acronym: CLIN EXP ALLERGY
Volume: 49
Issue: 4
First page : 442
Last page: 460
Number of pages: 19
ISSN: 0954-7894
DOI: https://doi.org/10.1111/cea.13333
Web address : https://onlinelibrary.wiley.com/doi/full/10.1111/cea.13333
Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users.Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.