A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer
Tekijät: Diederick Duijvesz, C. Yin L. Versluis,†, Christa A.M. van der Fels, Mirella S. Vredenbregt-van den Berg, Janne Leivo, Mari T. Peltola, Chris H. Bangma, Kim S.I. Pettersson, Guido Jenster
Kustantaja: WILEY-BLACKWELL
Julkaisuvuosi: 2015
Journal: International Journal of Cancer
Tietokannassa oleva lehden nimi: INTERNATIONAL JOURNAL OF CANCER
Lehden akronyymi: INT J CANCER
Vuosikerta: 137
Numero: 12
Aloitussivu: 2869
Lopetussivu: 2878
Sivujen määrä: 10
ISSN: 0020-7136
DOI: https://doi.org/10.1002/ijc.29664
What's new? The vesicles cast off by cancer cells could serve as billboards advertising the cancer's presence - if we knew how to read them. Detecting markers in prostate cancer vesicles is currently labor intensive. These authors set out to change that, by developing an immunoaffinity technique to expose these cellular markers more easily. Using the assay, they detected two cell surface proteins, CD9 and CD63, in the urine of men who had prostate cancer. They found far less of the markers in men without cancer, men without prostates, and women, suggesting CD9 and CD63 could be useful prostate cancer markers.
