Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

: Hirvonen J, Virtanen KA, Nummenmaa L, Hannukainen JC, Honka MJ, Bucci M, Nesterov SV, Parkkola R, Rinne J, Iozzo P, Nuutila P

Publisher: AMER DIABETES ASSOC

: 2011

: Diabetes

: DIABETES

: 2

: 60

: 2

: 443

: 447

: 5

: 0012-1797

DOI: https://doi.org/10.2337/db10-0940

CONCLUSIONS-We found that insulin stimulates brain glucose metabolism at physiological postprandial levels in patients with impaired glucose tolerance but not in healthy subjects. These results suggest that insulin stimulation of brain glucose metabolism is maximal at fasting concentrations in healthy subjects but not in patients with impaired glucose tolerance. Diabetes 60:443-447, 2011