Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance - UTU Research Portal

A1 Refereed original research article in a scientific journal

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

Authors: Hirvonen J, Virtanen KA, Nummenmaa L, Hannukainen JC, Honka MJ, Bucci M, Nesterov SV, Parkkola R, Rinne J, Iozzo P, Nuutila P

Publisher: AMER DIABETES ASSOC

Publication year: 2011

Journal: Diabetes

Journal name in source: DIABETES

Journal acronym: DIABETES

Number in series: 2

Volume: 60

Issue: 2

First page : 443

Last page: 447

Number of pages: 5

ISSN: 0012-1797

DOI: https://doi.org/10.2337/db10-0940

Abstract

CONCLUSIONS-We found that insulin stimulates brain glucose metabolism at physiological postprandial levels in patients with impaired glucose tolerance but not in healthy subjects. These results suggest that insulin stimulation of brain glucose metabolism is maximal at fasting concentrations in healthy subjects but not in patients with impaired glucose tolerance. Diabetes 60:443-447, 2011