A1 Refereed original research article in a scientific journal
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Authors: Middeldorp CM, Mahajan A, Horikoshi M, Robertson NR, Beaumont RN, Bradfield JP, Bustamante M, Cousminer DL, Day FR, De Silva NM, Guxens M, Mook-Kanamori DO, St Pourcain B, Warrington NM, Adair LS, Ahlqvist E, Ahluwalia TS, Almgren P, Ang W, Atalay M, Auvinen J, Bartels M, Beckmann JS, Bilbao JR, Bond T, Borja JB, Cavadino A, Charoen P, Chen ZH, Coin L, Cooper C, Curtin JA, Custovic A, Das S, Davies GE, Dedoussis GV, Duijts L, Eastwood PR, Eliasen AU, Elliott P, Eriksson JG, Estivill X, Fadista J, Fedko IO, Frayling TM, Gaillard R, Gauderman WJ, Geller F, Gilliland F, Gilsanz V, Granell R, Grarup N, Groop L, Hadley D, Hakonarson H, Hansen T, Hartman CA, Hattersley AT, Hayes MG, Hebebrand J, Heinrich J, Helgeland O, Henders AK, Henderson J, Henriksen TB, Hirschhorn JN, Hivert MF, Hocher B, Holloway JW, Holt P, Hottenga JJ, Hypponen E, Iniguez C, Johansson S, Jugessur A, Kahonen M, Kalkwarf HJ, Kaprio J, Karhunen V, Kemp JP, Kerkhof M, Koppelman GH, Korner A, Kotecha S, Kreiner-Moller E, Kulohoma B, Kumar A, Kutalik Z, Lahti J, Lappe JM, Larsson H, Lehtimaki T, Lewin AM, Li J, Lichtenstein P, Lindgren CM, Lindi V, Linneberg A, Liu XP, Liu J, Lowe WL, Lundstrom S, Lyytikainen LP, Ma RCW, Mace A, Magi R, Magnus P, Mamun AA, Mannikko M, Martin NG, Mbarek H, McCarthy NS, Medland SE, Melbye M, Melen E, Mohlke KL, Monnereau C, Morgen CS, Morris AP, Murray JC, Myhre R, Najman JM, Nivard MG, Nohr EA, Nolte IM, Ntalla I, O'Reilly P, Oberfield SE, Oken E, Oldehinkel AJ, Pahkala K, Palviainen T, Panoutsopoulou K, Pedersen O, Pennell CE, Pershagen G, Pitkanen N, Plomin R, Power C, Prasad RB, Prokopenko I, Pulkkinen L, Raikkonen K, Raitakari OT, Reynolds RM, Richmond RC, Rivadeneira F, Rodriguez A, Rose RJ, Salem R, Santa-Marina L, Saw SM, Schnurr TM, Scott JG, Selzam S, Shepherd JA, Simpson A, Skotte L, Sleiman PMM, Snieder H, Sorensen TIA, Standl M, Steegers EAP, Strachan DP, Straker L, Strandberg T, Taylor M, Teo YY, Thiering E, Torrent M, Tyrrell J, Uitterlinden AG, van Beijsterveldt T, van der Most PJ, van Duijn CM, Viikari J, Vilor-Tejedor N, Vogelezang S, Vonk JM, Vrijkotte TGM, Vuoksimaa E, Wang CA, Watkins WJ, Wichmann HE, Willemsen G, Williams GM, Wilson JF, Wray NR, Xu SJ, Xu CJ, Yaghootkar H, Yi L, Zafarmand MH, Zeggini E, Zemel BS, Hinney A, Lakka TA, Whitehouse AJO, Sunyer J, Widen EE, Feenstra B, Sebert S, Jacobsson B, Njolstad PR, Stoltenberg C, Smith GD, Lawlor DA, Paternoster L, Timpson NJ, Ong KK, Bisgaard H, Bonnelykke K, Jaddoe VWV, Tiemeier H, Jarvelin MR, Evans DM, Perry JRB, Grant SFA, Boomsma DI, Freathy RM, McCarthy MI, Adair LS, Ahlqvist E, Ahluwalia TS, Almgren P, Ang W, Atalay M, Beaumont RN, Beckmann JS, Bisgaard H, Bond T, Bonnelykke K, Boomsma DI, Borja JB, Bradfield JP, Bustamante M, Cavadino A, Charoen P, Coin L, Cooper C, Cousminer DL, Curtin JA, Custovic A, Das S, Day FR, De Silva NM, Dedoussis GV, Elliott P, Eriksson JG, Evans DM, Fadista J, Feenstra B, Felix JF, Frayling TM, Freathy RM, Gaillard R, Geller F, Gilsanz V, Grant SFA, Grarup N, Groop L, Guxens M, Hadley D, Hakonarson H, Hansen T, Hattersley AT, Hayes MG, Hebebrand J, Heinrich J, Helgeland O, Henriksen TB, Hinney A, Hirschhorn JN, Hivert MF, Hocher B, Holloway JW, Horikoshi M, Hottenga JJ, Hypponen E, Jacobsson B, Jaddoe VWV, Jarvelin MR, Johansson S, Kalkwarf HJ, Kerkhof M, Korner A, Kotecha S, Kreiner-Moller E, Kulohoma B, Kutalik Z, Lakka TA, Lappe JM, Lawlor DA, Lehtimaki T, Lewin AM, Lindgren CM, Lindi V, Linneberg A, Liu XP, Liu J, Lowe WL, Ma RCW, Mace A, Magi R, Magnus P, Mahajan A, McCarthy NS, McCarthy MI, Melbye M, Mohlke KL, Monnereau C, Mook-Kanamori DO, Morgen CS, Morris AP, Murray JC, Myhre R, Njolstad PR, Nohr EA, Ntalla I, O'Reilly P, Oberfield SE, Oken E, Ong KK, Panoutsopoulou K, Pedersen O, Pennell CE, Perry JRB, Pitkanen N, St Pourcain B, Power C, Prasad RB, Prokopenko I, Raitakari OT, Reynolds RM, Richmond RC, Rodriguez A, Salem R, Saw SM, Schnurr TM, Sebert S, Shepherd JA, Simpson A, Skotte L, Sorensen TIA, Standl M, Steegers EAP, Strachan DP, Sunyer J, Taylor M, Teo YY, Thiering E, Timpson NJ, Tyrrell J, Uitterlinden AG, van Duijn CM, Vogelezang S, Vrijkotte TGM, Wang CA, Warrington NM, Watkins WJ, Wichmann HE, Widen EE, Willemsen G, Wilson JF, Yaghootkar H, Zafarmand MH, Zeggini E, Zemel BS, Ahluwalia TS, Auvinen J, Bartels M, Bilbao JR, Bisgaard H, Bonnelykke K, Boomsma DI, Bradfield JP, Bustamante M, Chen ZH, Curtin JA, Custovic A, Smith GD, Davies GE, Duijts L, Eastwood PR, Eliasen AU, Estivill X, Evans DM, Fedko IO, Felix JF, Gauderman WJ, Gilliland F, Granell R, Grant SFA, Guxens M, Hakonarson H, Hartman CA, Heinrich J, Henders AK, Henderson J, Holt P, Hottenga JJ, Hypponen E, Iniguez C, Jacobsson B, Jaddoe VWV, Jarvelin MR, Jugessur A, Kahonen M, Kaprio J, Karhunen V, Kemp JP, Koppelman GH, Kumar A, Lahti J, Larsson H, Lawlor DA, Lehtimaki T, Li J, Lichtenstein P, Lundstrom S, Lyytikainen LP, Magnus P, Mamun AA, Mannikko M, Martin NG, Mbarek H, Medland SE, Melen E, Middeldorp CM, Najman JM, Nivard MG, Nolte IM, Oldehinkel AJ, Pahkala K, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pitkanen N, Plomin R, St Pourcain B, Power C, Pulkkinen L, Raikkonen K, Raitakari OT, Richmond RC, Rivadeneira F, Rose RJ, Santa-Marina L, Scott JG, Sebert S, Selzam S, Simpson A, Sleiman PMA, Snieder H, Standl M, Stoltenberg C, Strachan DP, Straker L, Strandberg T, Sunyer J, Thiering E, Tiemeier HN, Timpson NJ, Torrent M, Uitterlinden AG, van Beijsterveldt T, van der Most PJ, van Duijn CM, Viikari J, Vilor-Tejedor N, Vonk JM, Vrijkotte TGM, Vuoksimaa E, Wang CA, Whitehouse AJO, Willemsen G, Williams GM, Wray NR, Xu SJ, Xu CJ, Yi L, Zafarmand MH, Zafarmand MH
Publisher: SPRINGER
Publication year: 2019
Journal: European Journal of Epidemiology
Journal name in source: EUROPEAN JOURNAL OF EPIDEMIOLOGY
Journal acronym: EUR J EPIDEMIOL
Volume: 34
Issue: 3
First page : 279
Last page: 300
Number of pages: 22
ISSN: 0393-2990
DOI: https://doi.org/10.1007/s10654-019-00502-9
Web address : https://link.springer.com/article/10.1007/s10654-019-00502-9
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/40217226
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
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