Gene Expression Profiling of Endometrial Adenocarcinomas Reveals Increased Apolipoprotein E Expression in Poorly Differentiated Tumors



: Huvila J, Brandt A, Rojas CR, Pasanen S, Talve L, Hirsimaki P, Fey V, Kytomaki L, Saukko P, Carpen O, Soini JT, Grenman S, Auranen A

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2009

: International Journal of Gynecological Cancer

: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

: INT J GYNECOL CANCER

: 19

: 7

: 1226

: 1231

: 6

: 1048-891X

DOI: https://doi.org/10.1111/IGC.0b013e3181b33be0


Conclusions: Increased expression of APOE might represent a late event in the progression of well-differentiated endometrioid endometrial adenocarcinoma to a poorly differentiated endometrioid endometrial adenocarcinoma. Although increased APOE expression has been previously reported in other malignancies, this is the first study to suggest that APOE might also have a role in endometrioid endometrial cancer.



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