A1 Refereed original research article in a scientific journal
Gene Expression Profiling of Endometrial Adenocarcinomas Reveals Increased Apolipoprotein E Expression in Poorly Differentiated Tumors
Authors: Huvila J, Brandt A, Rojas CR, Pasanen S, Talve L, Hirsimaki P, Fey V, Kytomaki L, Saukko P, Carpen O, Soini JT, Grenman S, Auranen A
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2009
Journal: International Journal of Gynecological Cancer
Journal name in source: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Journal acronym: INT J GYNECOL CANCER
Volume: 19
Issue: 7
First page : 1226
Last page: 1231
Number of pages: 6
ISSN: 1048-891X
DOI: https://doi.org/10.1111/IGC.0b013e3181b33be0
Abstract
Conclusions: Increased expression of APOE might represent a late event in the progression of well-differentiated endometrioid endometrial adenocarcinoma to a poorly differentiated endometrioid endometrial adenocarcinoma. Although increased APOE expression has been previously reported in other malignancies, this is the first study to suggest that APOE might also have a role in endometrioid endometrial cancer.
Conclusions: Increased expression of APOE might represent a late event in the progression of well-differentiated endometrioid endometrial adenocarcinoma to a poorly differentiated endometrioid endometrial adenocarcinoma. Although increased APOE expression has been previously reported in other malignancies, this is the first study to suggest that APOE might also have a role in endometrioid endometrial cancer.
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