A1 Refereed original research article in a scientific journal
Covalently Palladated Oligonucleotides Through Oxidative Addition of Pd-0
Authors: Räisälä H., Lönnberg T.
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2019
Journal: Chemistry - A European Journal
Journal name in source: CHEMISTRY-A EUROPEAN JOURNAL
Journal acronym: CHEM-EUR J
Volume: 25
Issue: 18
First page : 4751
Last page: 4756
Number of pages: 6
ISSN: 0947-6539
eISSN: 1521-3765
DOI: https://doi.org/10.1002/chem.201806022
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/39976443
An 11-mer oligonucleotide incorporating a central (2-iodobenzoylamino)methyl residue has been synthesized and palladated by oxidative addition of Pd-2(dba)(3). UV melting profiles of the duplexes formed by the palladated oligonucleotide with its natural complements were biphasic and the higher melting temperatures (T-m) exhibited considerable hysteresis. CD spectra, in turn, resembled those of canonical B-type double helices. Two-step denaturation, with the "low-T-m"melting involving only canonical base pairs and the "high-T-m" melting involving also dissociation of a Pd-II-mediated base pair, appears the most likely explanation for the observed UV melting profiles. As the latter step in all cases takes place at a higher temperature than denaturation of natural duplexes of the same length, the putative Pd-II-mediated base pairs are stabilizing.
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