Intrapericardial, But Not Extrapericardial, Fat Is an Independent Predictor of Impaired Hyperemic Coronary Perfusion in Coronary Artery Disease
: Bucci M, Joutsiniemi E, Saraste A, Kajander S, Ukkonen H, Saraste M, Pietila M, Sipila HT, Teras M, Maki M, Airaksinen KEJ, Hartiala J, Knuuti J, Iozzo P
Publisher: LIPPINCOTT WILLIAMS & WILKINS
: 2011
: Arteriosclerosis, Thrombosis, and Vascular Biology
: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
: ARTERIOSCL THROM VAS
: 1
: 31
: 1
: 211
: 218
: 11
: 1079-5642
DOI: https://doi.org/10.1161/ATVBAHA.110.213827(external)
Conclusion-CAD is accompanied by augmented fat depots surrounding the heart, which are negatively related to coronary flow hyperemia. Among fat depots, IPF was the only independent predictor of hyperemic MBF, supporting the hypothesis of a direct paracrine/vasocrine effect. (Arterioscler Thromb Vasc Biol. 2011;31:211-218.)