Intrapericardial, But Not Extrapericardial, Fat Is an Independent Predictor of Impaired Hyperemic Coronary Perfusion in Coronary Artery Disease




Bucci M, Joutsiniemi E, Saraste A, Kajander S, Ukkonen H, Saraste M, Pietila M, Sipila HT, Teras M, Maki M, Airaksinen KEJ, Hartiala J, Knuuti J, Iozzo P

PublisherLIPPINCOTT WILLIAMS & WILKINS

2011

Arteriosclerosis, Thrombosis, and Vascular Biology

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ARTERIOSCL THROM VAS

1

31

1

211

218

11

1079-5642

DOIhttps://doi.org/10.1161/ATVBAHA.110.213827(external)



Conclusion-CAD is accompanied by augmented fat depots surrounding the heart, which are negatively related to coronary flow hyperemia. Among fat depots, IPF was the only independent predictor of hyperemic MBF, supporting the hypothesis of a direct paracrine/vasocrine effect. (Arterioscler Thromb Vasc Biol. 2011;31:211-218.)



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