Rifampicin markedly decreases the exposure to oral and intravenous tramadol

: Saarikoski T, Saari TI, Hagelberg NM, Neuvonen M, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K

Publisher: SPRINGER HEIDELBERG

: 2013

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 6

: 69

: 6

: 1293

: 1301

: 9

: 0031-6970

DOI: https://doi.org/10.1007/s00228-012-1460-x

Rifampicin markedly decreased the exposure to tramadol and M1 after both oral and intravenous administration. Therefore, rifampicin and other potent enzyme inducers may have a clinically important interaction with tramadol regardless of the route of its administration.