A1 Refereed original research article in a scientific journal

Rifampicin markedly decreases the exposure to oral and intravenous tramadol



Authors: Saarikoski T, Saari TI, Hagelberg NM, Neuvonen M, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K

Publisher: SPRINGER HEIDELBERG

Publication year: 2013

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Number in series: 6

Volume: 69

Issue: 6

First page : 1293

Last page: 1301

Number of pages: 9

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-012-1460-x


Abstract
Rifampicin markedly decreased the exposure to tramadol and M1 after both oral and intravenous administration. Therefore, rifampicin and other potent enzyme inducers may have a clinically important interaction with tramadol regardless of the route of its administration.



Last updated on 2024-26-11 at 22:44